Download e-book for iPad: Advances in Peptic Ulcer Pathogenesis by W.D. Rees

By W.D. Rees

over the last decade loads of examine task has happened on both sides of the gastroduodenal epithelial interface, with the typical target of elucidating the mechanisms of mucosal defense and the way those might be compromised in peptic ulcer illness. a chief stimulus to such examine has been the conclusion that irregular acid secretion or its supply into the duodenum in over the top volume can't totally clarify ulcer pathogenesis within the majority of sufferers. One could envisage the tummy and proximal duodenum as being in a dynamic equilibrium, with competitive luminal components, resembling acid and pepsin, being counteracted by means of protecting mucosal mechanisms. until eventually lately, the mechanisms concerned about mucosal defense have been poorly outlined whereas the body structure and pathophysiology of acid and pepsin secretion were elucidated. The effect that gastroduodenal mucosa was once safe by means of a unmarried mechanism has ultimately been changed by way of a extra practical view, suggesting a couple of protecting zones appearing in sequence. a few of these zones may perhaps act as first or moment line defences opposed to competitive elements whereas definite zones could in particular shield opposed to yes aggressors.

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Advances in Peptic Ulcer Pathogenesis by W.D. Rees

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